The actual number of cases may be higher, as some people with Peyronie’s disease may feel embarrassed and choose not to get help.Įxperts do not know the exact cause of Peyronie’s disease. While the condition can affect males of any age, research suggests that males in their 60s are most commonly affected. Other evidence notes that 0.5% of adult American males receive a diagnosis of Peyronie’s disease. These hard plaques can be painful and cause the penis to curve during erections.Īccording to the Urology Care Foundation, Peyronie’s disease affects about 4 out of 100 men between the ages of 40–70 years. Peyronie’s disease is a condition where fibrous scar tissue, also known as plaques, forms under the skin anywhere on the penis. A person may first notice the curve during puberty, or may recognize it as always being slightly curved.Ī significant curve may cause pain or discomfort when a person has an erection, and can occur due to a congenital or acquired condition. There is some evidence that it may effectively break down the penile adhesions in Peyronie’s disease.A curved penis is normal, and many people have a slight bend or curve in their penis. ![]() More recently, the use of penile traction (with the Andropenis penile extender) for four to ten hours each day over a period of three to six months has been used. The most logical injected agent to use is collagenase, an enzyme that attacks collagen, the major component of Peyronie's plaques the effects of this, however, are disappointing and collagenase treatment is not available on the NHS. Steroids have also been used but produce unwanted side effects such as destruction of healthy tissues. Injection treatment with agents such as dimethyl sulfoxide, steroids, and calcium channel blockers directly into the plaques is used by some doctors none of these techniques has, however, produced convincing results. The only medical treatment proven to be effective is Tamoxifen, taken for six weeks, but this is only indicated in the early, painful stage of the disease given at the right time, Tamoxifen can relieve the pain and limit any subsequent bending of the penis. Similar inconclusive success has been attributed to para-aminobenzoate (Potaba®) tablets. Some clinicians have given men with Peyronie's disease vitamin E tablets as yet, no studies have ever established the effectiveness of vitamin E therapy. During the wait for improvement, however, patients are often willing to undergo treatments that have no scientifically proven effectiveness. Spontaneous improvement in the disease is seen in 60 to 70% of patients. Because the plaque of Peyronie's disease often shrinks or disappears without treatment over a six to 15 month period, medical experts suggest waiting one to two years before attempting to correct it surgically. Experts usually recommend surgery only in long-term cases where the disease has stabilised and where the deformity prevents intercourse. There is no strong evidence that any treatment other than surgery is effective. Providing education about the disease and its course is often all that is required. The goal of any treatment is to keep the Peyronie's patient sexually active. Men with Peyronie's disease usually seek medical attention because of painful erections or difficulty with intercourse. There is an association with high blood pressure, diabetes, raised cholesterol levels, ischaemic heart disease and arteriosclerosis as well as with certain drugs (beta blockers, anti-ulcer agents, antidepressants and antihistamines). ![]() Neither does it explain why some cases disappear quickly. While trauma might explain acute cases of Peyronie's disease, it does not explain why most cases develop slowly, with no apparent traumatic event. In more persistent cases, the plaque undergoes scarring due to formation of tough, fibrous tissue and may even form calcium deposits. In most patients, however, the injury heals within a year and the plaque does not advance beyond an initial inflammatory phase. The damaged area may heal slowly but abnormally. ![]() In older men, diminished elasticity, disease of the arteries and diabetes, may further increase the chances of injury. If the penis is abnormally squeezed or flexed, the area where the septum attaches to the elastic fibres may over stretch, injuring the lining of the erectile chamber and rupturing small blood vessels. A connecting tissue, called a septum, runs between the two chambers and attaches at the top and bottom of the penis. The inner membrane of each chamber is a sheath of elastic fibres. There are two erectile cylinders which run the length of the penis.
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